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Hudson River PCBs Superfund Site

Human Health Tables

PCB Cancer Slope Factors

Route of Exposure

Cancer Slope Factor

High Risk and Persistence

Ingestion

- Food Chain Exposure (i.e., fish)

- Sediment or soil ingestion

- Persistence of dioxin-like, tumor-promoting, or persis-   tent congeners in other media

- Early-life exposrue (all path-ways and mixtures)

2 mg/kg-day

Dermal

- If an absorption factor has been applied to reduce the   external dose

2 mg/kg-day

Inhalation

- Dust or aerosol inhalation

2 mg/kg-day

Low Risk and Persistence

Ingestion

- Water-soluble congeners

0.4 mg/kg-day

Inhalation

- Evaporated congeners

0.4 mg/kg-day

Dermal

- If no absoprtion factor has been applied to reduce the   external dose.

0.4 mg/kg-day

Lowest Risk and Persistence

Congener or isomer analyses verify that congeners with more than 4 chlorides comprise less than 2% of total PCBs

0.07 mg/kg-day

To calculate probabilities of risk of developing cancer, the slope factors are combined with information on exposure to the chemical through air, water, fish ingestion or soil and a probability is calculated.

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Non-cancer toxicity for Aroclor 1254 and Aroclor 1016

Aroclor

Study

NOAEL/LOAEL

Uncertainty Factor

Reference Dose in mg/kg-day

 

1254

Decreased antibody response

Ocular exudate

Inflamed Meiobian

glands (on interior of

eyelid)

Distorted fingernails

0.005 (LOAEL)

300

0.00002

1248

NA

 

 

1016

Reduced Birth Weight

0.007 (NOAEL)

100

0.00007

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