Hudson River PCBs Superfund Site
Human Health Tables
PCB Cancer Slope Factors
Route of Exposure |
Cancer Slope Factor |
High Risk and Persistence |
|
Ingestion - Food Chain Exposure (i.e., fish) - Sediment or soil ingestion - Persistence of dioxin-like, tumor-promoting, or persis- tent congeners in other media - Early-life exposrue (all path-ways and mixtures) |
2 mg/kg-day |
Dermal - If an absorption factor has been applied to reduce the external dose |
2 mg/kg-day |
Inhalation - Dust or aerosol inhalation |
2 mg/kg-day |
Low Risk and Persistence |
|
Ingestion - Water-soluble congeners |
0.4 mg/kg-day |
Inhalation - Evaporated congeners |
0.4 mg/kg-day |
Dermal - If no absoprtion factor has been applied to reduce the external dose. |
0.4 mg/kg-day |
Lowest Risk and Persistence |
|
Congener or isomer analyses verify that congeners with more than 4 chlorides comprise less than 2% of total PCBs |
0.07 mg/kg-day |
To calculate probabilities of risk of developing cancer, the slope factors are combined with information on exposure to the chemical through air, water, fish ingestion or soil and a probability is calculated.
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Non-cancer toxicity for Aroclor 1254 and Aroclor 1016
Aroclor |
Study |
NOAEL/LOAEL |
Uncertainty Factor |
Reference Dose in mg/kg-day |
1254 |
Decreased antibody response Ocular exudate Inflamed Meiobian glands (on interior of eyelid) Distorted fingernails |
0.005 (LOAEL) |
300 |
0.00002 |
1248 |
NA |
|
|
|
1016 |
Reduced Birth Weight |
0.007 (NOAEL) |
100 |
0.00007 |