Web-based Interspecies Correlation Estimation (Web-ICE) estimates the acute toxicity of a chemical to a taxon (i.e., the predicted species, genera, or family) without test data from the known toxicity of the chemical to a species with test data (the surrogate). ICE models are least square regressions between the surrogate species and the predicted taxa to estimate the toxicity of that chemical to the predicted species, genus or family.
Web-ICE expands the fundamental ground work of ICE v.1.0 (Asfaw et al. 2003) as an internet application to include additional chemical and species toxicity data yielding increased interspecies correlations. This manual provides step-by-step instructions for using Web-ICE, as well as information on the expanded databases, model development, model validation, and user guidance on model selection and interpretation.