Jump to main content or area navigation.

Contact Us

CADDIS Volume 3: Examples & Applications


Metals Chronic Concentration-Response Gallery

The Metals Chronic Concentration-Response Gallery is a gallery of plots and source data describing the responses of aquatic organisms to chronic exposures to metals, including arsenic, cadmium, chromium, copper, lead, mercury, nickel, selenium and zinc. These data are particularly valuable because they include longer term exposures, multiple life stages and sublethal as well as lethal effects. Results are presented as fitted functions and concentrations resulting in prescribed proportions affected (EC5, EC10, EC20 and EC50). Confidence intervals may be found in the Model Parameters and Benchmarks worksheets.

Example modeled and interpolated stressor response relationships
Figure 1. Examples of modeled and interpolated plots from the Metals Chronic Exposure-Reponse Gallery

What are the source data for these plots?

The data used for these plots were extracted from toxicity test results originally published between 1968 and 1996. The tests selected were judged to be suitable for deriving national ambient water quality criteria by the database developers, David Hansen and Glenn Thursby of the U.S. EPA National Health and Environmental Effects Research Laboratory in Narragansett, RI. The version of the data base used here was quality assured, edited, and published in U.S. EPA (2005). The References tab of this module lists that report and the statistical methods paper (Kerr and Meador 1996).

How were plots generated?

Plots were successfully modeled for 38 of the 120 datasets using the method described by Kerr and Meador (1996). Confidence intervals were calculated for both the exposure concentration (red dashed lines, Figure 1) and the proportion responding (blue dashed lines, Figure 1). Some papers reported only mean responses without standard deviations or results for replicates. For these sets, surrogate standard deviations were derived based on the expected variance for that type of response (see U.S. EPA 2005). Linear interpolation was also used to estimate the EC5, EC10, EC20 and EC50 benchmark values for those datasets exhibiting both a concentration-response relationship and sufficient data points (Figure 1, right). See U.S. EPA (2005) for more detail on the methods.

Download and browse the gallery

To download the gallery and supporting information:

  1. Save Metal Chronic Concentration Response Gallery - V1 (1.7MB, .zip) to your computer.
  2. Unzip the file by right clicking on the folder and selecting "extract all" to invoke the extraction wizard.

To browse the gallery and supporting information:

  1. Open the file titled "Start Here - Chronic Metals Concentration Response Gallery V1.xls"
  2. Enable macros and open as "read only" (if you wish to modify this file, open as read only, make your changes, then save it under a different name).
  3. Review the background information before selecting the plots and source data of interest using the Browse the Chronic Metals Gallery worksheet.

Top of page

Jump to main content.